Ivan Tarle, MD PhD

1911 N. Mills Ave. Orlando, FL 32803
About Dr. Tarle
Cosmetic Services Available
Hospital Affiliations
Insurances Accepted
Map and Contact Information
post-graduate training
- University of Cincinnati, Cincinnati OH. Oculoplastics Fellow, July 2000-June 2001. Dwight R. Kulwin, M.D., Fellowship Director. Robert C. Kersten, M.D. Associate Director
- University of South Florida, Tampa FL. Ophthalmology Resident, July 1997-June 2000. Peter R. Pavan, M.D., Department Chair. 12901 Bruce B. Downs Blvd., MDC 21 Tampa, FL 33612
- University of Tennessee School of Medicine, Memphis TN. Chattanooga Unit.Transitional Year Intern, July 1996-June 1997. Mukta Panda, M.D., Program Director. Erlanger Medical Center – Medicine Clinic
975 East Third Street. Chattanooga, TN 37403
EDUCATION
- M.D., Ph.D., Washington University School of Medicine. St. Louis, Missouri, (Ph.D. in Biochemistry). August 1987-May 1996.
- Medical Scientist Training Program. National Eye Institute Predoctoral Fellowship, 1991-1994. Ellis Award, 1994
- B.S., California Institute of Technology (Caltech)
- Pasadena, California. Major: Biology
Services that Dr. Tarle provides:
- Cosmetic surgery of eyelid and periocular tissues, with emphasis on upper and lower eyelid blepharoplasty, to remove and sculpt skin and fat. This also encompasses brow lifting, including endoscopic brow and forehead lifting as well as Botox Cosmetic.
- Surgical treatment of common eyelid disorders including correction of eyelid droop, malposition and retraction; excision of benign and malignant eyelid growths and subsequent eyelid reconstruction.
- Treatment of orbital and periorbital trauma including orbital fractures, eyelid lacerations and tear drainage system injuries.
- Treatment of orbital diseases such as thyroid eye disease, tumors, inflammation and infection.
- Treatment of tear drainage system abnormalities such as tear duct blockage with tearing, infection and dry eyes
Publications
- Tarle I, Borhani DW, Wilson DK, Quiocho FA, Petrash, JM. Probing the Active Site of Human Aldose Reductase: Site-directed Mutagenesis of Asp-43, Tyr-48, Lys-77 and His-110. J. Biol. Chem. 1993;268:25687-25693.
- Wilson DK, Tarle I, Petrash JM, Quiocho FA. Refined 1.8 � Structure of Human Aldose Reductase Complexed with the Potent Inhibitor Zopolrestat. Proc. Natl. Acad. Sci. USA 1993;90:9847-9851.
- Petrash JM, Harter TM, Tarle I, Borhani DW. Kinetic Alteration of Human Aldose Reductase by Mutagenesis of Cysteine Residues. In: Weiner H, ed. Enzymology and Molecular Biology of Carbonyl Metabolism, Vol. 4, New York: Plenum Press; 1993:289-300.
- Petrash JM, Tarle I, Wilson DK, Quiocho FA. Aldose Reductase Catalysis and Crystallography: Insights from Recent Advances in Enzyme Structure and Function. Diabetes 1994;43:955-959.
- Tarle I, Ph.D. Thesis. Probing Structure-Function Relationships at the Active Site of Human Aldose Reductase; St. Louis, Missouri, 1996.
- Valluri S, Fleming TP, Laycock KA, Tarle I, Goldberg MA, Garcia-Ferrer FJ, Essary LR, Pepose JS. In vitro and in vivo effects of polyhexamethylene biguanide against herpes simplex virus infection. Cornea 1997;16(5):556-9.
- Co-author for Malignant Mesenchymoma: Case Report with Review of Literature. Ophthalmology In press
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Orlando
1911 N. Mills Ave. Orlando, FL 32803 Phone: (407) 893-8200 Fax: (407) 893-8210
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Wekiva
2257 E. Semoran Blvd. Apopka, FL 32703 Phone:(407) 886-4878 Fax: (407) 886-9531
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Kissimmee
2065 E. Osceola Parkway Kissimmee, FL 34743 Phone:(407) 344-3603 Fax: (407) 344-3868
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Please also visit us at

www.MagruderEye.com
Graves' disease is an autoimmune disease. It most commonly affects the thyroid, causing it to grow to twice its size or more (goiter), be overactive, with related hyperthyroid symptoms such as increased heartbeat, muscle weakness, disturbed sleep, and irritability. It can also affect the eyes, causing bulging eyes (exophthalmos). It affects other systems of the body, including the skin and reproductive organs. It affects up to 2% of the female population, often appears after childbirth, and has a female:male incidence of 5:1 to 10:1. It has a strong hereditary component; when one identical twin has Graves' disease, the other twin will have it 25% of the time. Smoking and exposure to second-hand smoke is associated with the eye manifestations but not the thyroid manifestations. Diagnosis is usually made on the basis of symptoms, although thyroid hormone tests may be useful, particularly to monitor treatment.
Blepharoplasty can be both a functional and cosmetic surgical procedure intended to reshape the upper eyelid or lower eyelid by the removal or repositioning of excess tissue as well as by reinforcement of surrounding muscles and tendons
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A virus is a small infectious agent that can replicate only inside the living cells of other organisms. Most viruses are too small to be seen directly with a light microscope. Viruses infect all types of organisms, from animals and plants to bacteria and archaea.
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